Alexander the Great


Alexander the Great : biography

20 July 356 BC – 10 June 323 BC

While Alexander campaigned north, the Thebans and Athenians rebelled once again. Alexander immediately headed south. While the other cities again hesitated, Thebes decided to fight. The Theban resistance was ineffective, and Alexander razed the city and divided its territory between the other Boeotian cities. The end of Thebes cowed Athens, leaving all of Greece temporarily at peace. Alexander then set out on his Asian campaign, leaving Antipater as regent.


Apart from a few inscriptions and fragments, texts written by people who actually knew Alexander or who gathered information from men who served with Alexander were all lost. Contemporaries who wrote accounts of his life included Alexander’s campaign historian Callisthenes; Alexander’s generals Ptolemy and Nearchus; Aristobulus, a junior officer on the campaigns; and Onesicritus, Alexander’s chief helmsman. Their works are lost, but later works based on these original sources have survived. The earliest of these is Diodorus Siculus (1st century BC), followed by Quintus Curtius Rufus (mid-to-late 1st century AD), Arrian (1st to 2nd century AD), the biographer Plutarch (1st to 2nd century AD), and finally Justin, whose work dated as late as the 4th century. Of these, Arrian is generally considered the most reliable, given that he used Ptolemy and Aristobulus as his sources, closely followed by Diodorus.


Death and succession

On either 10 or 11 June 323 BC, Alexander died in the palace of Nebuchadnezzar II, in Babylon, at age 32. Details of the death differ slightly – Plutarch’s account is that roughly 14 days before his death, Alexander entertained admiral Nearchus, and spent the night and next day drinking with Medius of Larissa.

He developed a fever, which worsened until he was unable to speak. The common soldiers, anxious about his health, were granted the right to file past him as he silently waved at them. Diodorus recounts that Alexander was struck with pain after downing a large bowl of unmixed wine in honour of Hercules, and died after some agony. Arrian also mentioned this as an alternative, but Plutarch specifically denied this claim.

Given the propensity of the Macedonian aristocracy to assassination, foul play featured in multiple accounts of his death. Diodorus, Plutarch, Arrian and Justin all mentioned the theory that Alexander was poisoned. Plutarch dismissed it as a fabrication, while both Diodorus and Arrian noted that they mentioned it only for the sake of completeness.

The accounts were nevertheless fairly consistent in designating Antipater, recently removed as Macedonian viceroy, and at odds with Olympias, as the head of the alleged plot. Perhaps taking his summons to Babylon as a death sentence, and having seen the fate of Parmenion and Philotas, Antipater purportedly arranged for Alexander to be poisoned by his son Iollas, who was Alexander’s wine-pourer. There was even a suggestion that Aristotle may have participated.

The strongest argument against the poison theory is the fact that twelve days passed between the start of his illness and his death; such long-acting poisons were probably not available. In 2010, however, a new theory proposed that the circumstances of his death were compatible with poisoning by water of the river Styx (Mavroneri) that contained calicheamicin, a dangerous compound produced by bacteria.

Several natural causes (diseases) have been suggested, including malaria and typhoid fever. A 1998 article in the New England Journal of Medicine attributed his death to typhoid fever complicated by bowel perforation and ascending paralysis. Another recent analysis suggested pyrogenic spondylitis or meningitis. Other illnesses fit the symptoms, including acute pancreatitis and West Nile virus.

Natural-cause theories also tend to emphasise that Alexander’s health may have been in general decline after years of heavy drinking and severe wounds. The anguish that Alexander felt after Hephaestion’s death may also have contributed to his declining health. The most likely possible cause is an overdose of medication containing hellebore, which is deadly in large doses.