Avram Hershko bigraphy, stories - Israeli scientist

Avram Hershko : biography

December 31, 1937 -

Avram Hershko ( born 31 December 1937) is an Israeli biochemist and Nobel laureate in Chemistry.

Biography

Hershko was born Herskó Ferenc in Karcag, Hungary, the son of Shoshana Margit and Moshe Hershko, both teachers.http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2004/hershko-autobio.html Hershko emigrated to Israel in 1950. He Received his M.D. in 1965 and his Ph.D in 1969 from the Hebrew University-Hadassah Medical School, Jerusalem, Israel. He is currently a Distinguished Professor at the Rappaport Faculty of Medicine at the Technion in Haifa.

Along with Aaron Ciechanover and Irwin Rose, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as cancer, muscular and neurological diseases, and immune and inflammatory responses.

His contributions to science directly helped cure his long-time friend from cancer.

Honours and awards

  • 1987 – Weizmann Prize for Sciences (Israel)
  • 1994 – Israel Prize in biochemistry
  • 1999 – Gairdner International Award Canada (with A. Varshavsky)
  • 2000 – Albert Lasker Award for Basic Medical Research (with A. Ciechanover and A. Varshavsky).
  • 2001 – Louisa Gross Horwitz Prize from Columbia University
  • 2001 - Massry Prize from the Keck School of Medicine, University of Southern California
  • 2001 – Wolf Prize in Medicine (Israel), jointly with Alexander Varshavsky, for 'the discovery of the ubiquitin system of intracellular protein degradation and the crucial functions of this system in cellular regulation."
  • 2003 – Foreign Associate, National Academy of Sciences, USA
  • 2004 – Nobel Prize in Chemistry for his discovery with Aaron Ciechanover and Irwin Rose, of ubiquitin-mediated protein degradation. – A web article

In 2005, he was voted the co-31st-greatest Israeli of all time, in a poll by the Israeli news website Ynet to determine whom the general public considered the 200 Greatest Israelis. Hershko's work and reception of the Nobel Prize is cited as a historic milestone in the unique history of the Technion - Israel Institute of Technology.

Publications

  • Hershko, A., Ciechanover, A., Heller, H., Haas, A.L., and Rose I.A. (1980) "Proposed role of ATP in protein breakdown: Conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis". Proc. Natl. Acad. Sci. USA 77, 1783–1786.
  • Hershko, A., Heller, H., Elias, S. and Ciechanover, A. (1983) Components of ubiquitin-protein ligase system: resolution, affinity purification and role in protein breakdown. J. Biol. Chem. 258, 8206–8214.
  • Hershko, A., Leshinsky, E., Ganoth, D. and Heller, H. (1984) ATP-dependent degradation of ubiquitin-protein conjugates. Proc. Natl. Acad. Sci. USA 81, 1619–1623.
  • Hershko, A., Heller, H., Eytan, E. and Reiss, Y. (1986) The protein substrate binding site of the ubiquitin-protein ligase system. J. Biol. Chem. 261, 11992-11999.
  • Ganoth, D., Leshinsky, E., Eytan, E., and Hershko, A. (1988) A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of components and evidence for ATP-dependent complex formation. J. Biol. Chem. 263, 12412-1241.
  • Sudakin, V., Ganoth, D., Dahan, A., Heller, H., Hershko, J., Luca, F.C., Ruderman, J.V. and Hershko, A. (1995). The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell 6, 185–198.

Involvement with biotechnology

Professor Hershko serves on the Scientific Advisory Board of .

Living octopus

Living octopus

In countries which are located near sea coasts, sea food is an important part of national cuisine